The Center for Personalized Cancer Therapeutics

Cultivating and Administering Next-Generation Diagnostics and Treatments

Cancer ranks as the second leading cause of death in the United States, killing nearly as many people as heart disease. To combat this crisis, in July Mount Sinai launched the Center for Personalized Cancer Therapeutics (CPCT), within The Tisch Cancer Institute, where we are receiving the support necessary to elevate cancer therapy to a highly personalized level. Here is a brief overview of how our two labs are working to help cancer patients live longer while enjoying an improved quality of life.

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Mount Sinai Goes Courtside at the US Open

The Mount Sinai Medical Center—recently named the official medical service provider and hospital of the USTA and US Open—will provide on-site clinical care for tennis players competing in the US Open, held August 26 to September 9, in Flushing Meadows, Queens. Mount Sinai also is the official sponsor of Arthur Ashe Kids’ Day, an annual tennis event for children that was held Saturday, August 24.

The five-year partnership with the USTA calls for Mount Sinai to develop recommendations around injury prevention and management and conduct educational outreach on the health benefits of playing tennis. Alexis Chiang Colvin, MD, Assistant Professor of Sports Medicine in the Leni and Peter W. May Department of Orthopaedics at The Mount Sinai Medical Center, serves as Chief Medical Officer of the USTA and US Open, as well as Medical Advisor to the U.S. Fed Cup team.

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Accelerating Innovation and Discovery in the Biomedical Sciences

The Mount Sinai Medical Center is continuing its tradition of fostering breakthrough biomedical discoveries by nurturing a new breed of scientists. These scientists, both faculty and students, are exceptional men and women who have committed themselves to furthering medical science through innovation and are driving translational medicine using new tools, models, and approaches.

I am delighted to be part of this vision, which, combined with Mount Sinai’s history of world-class biomedical research, is now drawing students and faculty from quantitative sciences such as engineering and computer science, as well as other non-traditional backgrounds, to join in the process of creating new technologies for the prevention and treatment of human disease. For example, our recent academic affiliation with Rensselaer Polytechnic Institute, pools our expertise in biomedical research and patient care with Rensselaer’s talent in engineering and computational science. This unique partnership offers tremendous possibilities as it will enhance the infrastructure needed for translationally-focused faculty and students to develop novel biomedical technologies.

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The Mount Sinai Health System, A Bold New Chapter

The Mount Sinai Medical Center is about to embark on a new chapter, one that calls for growth and expansion through a planned combination with Continuum Health Partners, and continued success within a challenging health care environment.

That message was conveyed by leaders of The Mount Sinai Medical Center at three Town Hall meetings held on Tuesday, July 9, and Wednesday, July 10, in Stern Auditorium.

“Our combination with Continuum is about preserving Mount Sinai for decades to come as a great institution,” said Kenneth L. Davis, MD, President and Chief Executive Officer of The Mount Sinai Medical Center, before a standing-room-only crowd of faculty, staff, and students on Wednesday morning. “It is time that we move to the next step in health care and that is an integrated health care delivery system.”

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Unique Academic Affiliation Will Accelerate Innovation and Discovery in Biomedical Sciences

At the Icahn School of Medicine at Mount Sinai, we have taken a bold new approach to our pursuit of breakthrough discovery and innovation by forming an academic affiliation with Rensselaer Polytechnic Institute. Designed to pool our expertise in biomedical research and patient care and Rensselaer’s in engineering and invention prototyping, this affiliation will accelerate collaborations that support educational programs, research, and the development of diagnostic tools and treatments that promote human health.

With technology playing an increasingly important role in the diagnosis and treatment of disease, high competition for research funding, and the pharmaceutical industry investing less in research and development, Mount Sinai and Rensselaer are leveraging complementary strengths to revolutionize biomedical research and accelerate the pace of innovation and entrepreneurship across the health sciences. Read more

Happy Birthday Minerva!

A year ago, the Icahn School of Medicine at Mount Sinai (ISMMS) took a giant step toward tackling some of the most difficult questions in science and launched a new era in scientific computing by building and operating “Minerva,” an on-site supercomputer for genomics and other basic sciences. In that short time, Minerva has helped ISMMS scientists analyze major diseases such as cancer, diabetes and Alzheimer’s with more precision, and it has also brought the medical world closer to developing more effective drugs and obtaining more accurate pathology results.

Driving Personalized Cancer Therapy

Eric Schadt, PhD, Professor and Chair for Genetics and Genomic Sciences and Director of the Icahn Institute for Genomics and Multiscale Biology, and his team rank as Minerva’s biggest users. With their research studies offering novel insights into the evolution and signaling of different cancers, they have discovered a vast diversity in most tumors, a diversity that may continue to increase as the tumors mutate to evade treatment. This information has led them to understand that, although analyzing genetic data is vital to delivering the right treatment for a patient’s cancer, it is not the only piece of the puzzle.

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Exploring the Future of Medicine

Kenneth L. Davis, MD, President and Chief Executive Officer of The Mount Sinai Medical Center, discussed at an Aspen Ideas Festival preview event held recently at The Studio Museum in Harlem.

The talk, titled “The Future of Medicine,” was a prelude to a larger discussion in which he will participate at the Aspen Ideas Festival in June. Corby Kummer, Senior Editor of The Atlantic magazine interviewed Dr. Davis for 20 minutes before inviting questions from the audience of about 75 invited guests. The event also featured Thelma Golden, Director and Chief Curator of The Studio Museum, who was interviewed by the actor and writer Anna Deveare Smith.

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Precision Medicine at Mount Sinai

Integrating a Patient’s Clinical and Molecular Information for Improved Diagnosis and Treatment

We often hear about the “potential” that biomedical science and technology have to offer “the future of medicine.” At The Mount Sinai Medical Center, some 25,000 patients are living that future and receiving more precise, personalized care—in real time—based on their own DNA.

Each has enrolled in BioMe (TM), our robust biobank which is among the largest such repositories in the United States. It is also unique in that each patient has broadly consented to DNA sequencing, contact from researchers, and longitudinal studies stemming from the electronic medical record (EMR). Mount Sinai has implemented the Epic EMR system throughout its inpatient and outpatient services, the emergency department, pharmacy, and in many affiliate offices across the city.

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Changing Education Today to Create the Leaders of Tomorrow

Abraham Flexner published his landmark report on undergraduate and medical school preparation of physicians in 1910. Within a few decades and continuing throughout the remainder of the 20th century, there have been admonitions to enhance, overhaul, or abolish the “traditional” pre-med requirements that he established.

The reasons for this dissatisfaction are self-evident:

  • The pace of scientific discovery and its clinical application has far outstripped the current century-old requirements.
  • The age of information technology has made memorizing vast amounts of content unnecessary.
  • The current requirements lack clinical, scientific, and social relevance.
  • The traditional requirements are used to ‘cull the herd’ of talented aspiring physicians.
  • The requirements disproportionately disadvantage minority and female students who are desperately needed to maintain diversity in our healthcare workforce.
  • The requirements consume so much time and effort that few students end up being grounded in bioethics, social justice, and health policy.
  • A rigid and highly structured pre-medical curriculum, followed by a rigid and highly structured medical school curriculum, deprives students of the ability to develop the critically important skill of lifelong self-directed learning.

Perhaps most important, the current model has perpetuated “pre-med syndrome,” an undergraduate culture of aggressive competition for grades that runs counter to what we value most in medicine: academic and intellectual rigor, creative thinking, teamwork and collaboration, and social conscience.

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Muppets, Push-ups, Pears, and other Matters of the Heart

February is American Heart Month, the time of year when the nation turns its attention to cardiovascular disease and other matters of the heart. While many public service efforts this month focus on educating people about the warning signs and symptoms of heart attack and stroke, as members of the medical community we have a real opportunity to change the course of this disease by encouraging heart-healthy lifestyles well before risk factors develop.

Cardiovascular disease kills 7.3 million people across the globe each year, making it the world’s leading cause of death. In the United States alone, one in every three deaths is from heart disease and stroke, equal to 2,200 deaths per day. At Mount Sinai, our renowned Director of Mount Sinai Heart and Professor of Cardiology, Valentin Fuster, MD, PhD, believes these sobering statistics mandate a new approach to preventing cardiovascular disease that identifies people much earlier in order to promote a healthy heart.

A new Muppet with a heart for health

So what do Muppets, push-ups and pears have to do with it? Many children between the ages of three and six who live in Spain already know. Born in Barcelona, Dr. Fuster is the inspiration for Spain’s newest Muppet, Dr. Valentin Ruster, who has a passion for heart health and appears in the Spanish version of Sesame Street. The only physician in the Muppet cast, Dr. Ruster’s character teaches kids how to make healthy decisions, like choosing fruits and vegetables, and having fun with exercise.

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