Clinical Trial Now Available For Patients With HPV-positive Oropharyngeal Squamous Cell Carcinoma

A new therapeutic clinical trial is now available at Mount Sinai for patients with HPV-related oropharyngeal (tonsil and tongue base) cancer who are eligible to undergo robot-assisted surgery. This study tests a novel vaccine (ADXS11-001) that patients receive during a specific window prior to undergoing surgery.

“Instead of offering traditional surgery and radiation, we are offering a newer vaccine approach to try to fight the virus, which is the actual cause of the cancer, versus chasing it on the back side with radiation and surgery,“ says Brett Miles, DDS, MD, the surgical oncologist and co-investigator on the trial.

The vaccine uses a novel principle to stimulate the immune system. Most of the available HPV vaccines to date have been preventive vaccines that do not treat patients who have already been affected with the virus. The vaccine in this trial uses a therapeutic approach, which can be used in patients who already have HPV-related cancer.

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Eradicating Cervical Cancer

As an oncologist, I am often confronted with patients with advanced gynecologic malignancies with limited successful options to cure them. The success of treating and curing patients with cancer depends not only on the skills and technologies, it is very much dependent on the patients and the stage of their diseases. Too often, we are not able to detect these malignancies early because we do not know what causes the disease and there are no early detection tests so that by the time a patient is in my office, the disease is at an advanced stage.    Cervical cancer, however, is one of the few gynecologic malignancies that we know is caused by the Human Papillomavirus (HPV) that can be detected by a simple pap smear. Furthermore, cervical cancer can be prevented with an HPV vaccination.

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Flu Myths vs. Facts

Dr. Cindy Feely

In my daily practice at Primary Care Associates, I get asked many questions about the flu and the flu vaccine. Despite improved access to accurate, responsible information in the media and on the web, a number of myths about the flu and the vaccine still exist. So here it is, point-by-point, information for you to make informed choices for your healthcare.

Myth #1: The flu vaccine gives you the flu

Facts: The vaccine, including this year’s version, consists of a dead virus which cannot infect you. What it can do is make your body produce the antibodies necessary to fight that virus if you come in contact with a live version of it. The live virus is included in the Flu Mist – a nasal spray, not an injection – but it is engineered so that it will not make you sick.

Myth #2: If you weren’t vaccinated by November, there’s no point in getting it now

Facts: While we are seeing a large number of cases right now, the flu often doesn’t hit its peak until February or even March. And while it does take two weeks to be fully effective, the vaccine will help lessen the severity if you do get the flu.

Myth #3: There’s no treatment for the flu

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The Flu Epidemic: What YOU can do

Influenza has officially reached epidemic proportions in several regions of the United States. Approximately 7.3% of deaths (exceeding the 7.2% threshold) are now attributed to pneumonia and the flu, according to the Centers for Disease Control and PreventionMount Sinai is taking a number of actions in order to continue to provide optimal care to all of our patients and to protect our patients and staff from exposure to influenza.

What can you do to protect yourself and others from influenza?

  • It’s not too late to get vaccinated. Click here to make an appointment online with one of our primary care doctors or call 212-241-6585
  • Dr. Prarthana Beuria recommends being vigilant about washing hands every time you’re out in public and around lots of people, whether in the subway or at the office, and to avoid touching your face with your hands.
  • If you have the flu, Dr. Beuria recommends that you “stay home from work until the fever has been gone for 24 hours. If people around you have compromised immune systems, stay away.”

Click here to view the full infographic

  Aquí está la influenza gráfica en Español

Who is at risk of getting the flu?

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