Drug-induced liver injury (DILI) is the single most common reason for regulatory actions concerning drugs, including failure to gain approval for marketing, removal from the market place and restriction of prescribing indications.
DILI is also a significant cause of morbidity and mortality in many patient populations. Due to its idiosyncratic nature, variable presentation and the vast number of potential causative drugs as well as herbal and dietary supplements, DILI is often diagnosed late in its course when patients have severe liver disease. DILI, including acute liver failure requiring liver transplantation, can happen anytime to anyone taking medications, even over the counter medications. Unfortunately, there are no tests to predict who is at risk nor to diagnose this problem. Read more
One third of people in need of a kidney transplant will be blood type incompatible with their donor and even more will be incompatible because of harmful antibodies against their donor. Yet sometimes, one person’s incompatibility can be another’s blessing in disguise.
Take for example Gina Dosso and her sister Maria Dosso. Gina had kidney failure and was nearing dialysis. Her sister Maria decided that she would like to donate a kidney to her. Unfortunately, even though they were related, Gina’s blood had harmful antibodies that would have caused her body to reject Maria’s kidney. In fact, Gina’s blood had harmful antibodies to greater than 80% of the population making it very difficult to find her any compatible donor. But rather than give up, with the help of the Mount Sinai Kidney Transplant team, they were enlisted into the National Kidney Registry, an organization that helps incompatible people find other incompatible people to perform a kidney “swap” with.