As an oncologist, I am often confronted with patients with advanced gynecologic malignancies with limited successful options to cure them. The success of treating and curing patients with cancer depends not only on the skills and technologies, it is very much dependent on the patients and the stage of their diseases. Too often, we are not able to detect these malignancies early because we do not know what causes the disease and there are no early detection tests so that by the time a patient is in my office, the disease is at an advanced stage. Cervical cancer, however, is one of the few gynecologic malignancies that we know is caused by the Human Papillomavirus (HPV) that can be detected by a simple pap smear. Furthermore, cervical cancer can be prevented with an HPV vaccination.