Previous studies have shown that there is a clear relationship between physical activity and higher bone mineral density (BMD). Exercise and the force that muscle contraction applies to bone improve skeletal health by stimulating the formation of new bone. Conversely, off-loading muscle, such as in astronauts, can lead to bone loss and an increased fracture risk. But the question of how muscle function regulates bone mass has remained largely unresolved despite their close anatomical proximity. A key question is whether muscle contraction connects to bone mass regulation through a secreted molecule. Read more
The results of a multicenter clinical trial led by Mount Sinai Health System researchers and published in The New England Journal of Medicine on October 1, 2015, demonstrate that brodalumab, an experimental biologic treatment for plaque psoriasis, achieved 100 percent reduction in psoriasis symptoms in twice as many patients as a second, commonly used treatment. Read more
Repeated exposure to anesthesia early in life causes changes in emotional behavior that may persist long-term, according to new research from the Icahn School of Medicine at Mount Sinai.
The findings, published in the August 2015 Online First edition of Anesthesiology, mark the first time nonhuman primates have been found to experience long-term behavioral changes resulting from repeated postnatal exposure to anesthesia. Prior results have shown that baby rodents also experience cognitive impairments later in life stemming from early anesthesia exposure. Read more
Leticia Tordesillas, PhD, and Elizabeth Heller, PhD, are the recipients of the 2015 Robin Chemers Neustein Postdoctoral Fellowship Award, which was created to encourage and support female research scientists at Icahn School of Medicine at Mount Sinai.
Dr. Tordesillas works in the laboratory of Cecilia Berin, PhD, Associate Professor of Pediatrics. Her research is focused on how to establish immune tolerance to foods for the treatment of food allergy. In particular, she is studying how regulatory T cells induced by epicutaneous immunotherapy are generated and suppress anaphylaxis. Read more
In a screen of more than 100,000 potential drugs, only one, harmine, drove human insulin-producing beta cells to multiply, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai, published in Nature Medicine.
Diabetes results from too few insulin-producing “beta cells” in the pancreas secreting too little insulin, the hormone required to keep blood sugar levels in the normal range. In a groundbreaking Mount Sinai study, researchers found that harmine drove the sustained division and multiplication of adult human beta cells in culture, a feat that had eluded the field for years. In addition, harmine treatment tripled the number of beta cells and led to better control of blood sugar in three groups of mice engineered to mimic human diabetes. Read more
Andrew Stewart, MD, the Irene and Dr. Arthur M. Fishberg Professor of Medicine and Director of Mount Sinai’s Diabetes, Obesity and Metabolism Institute led a team of scientists who discovered a novel mechanism that regulates the replication of insulin-producing beta cells in the pancreas. Their findings provided novel working models describing the control of cell cycle progression in the human beta cell. These discoveries offer new insights into possible therapeutic approaches to stimulate the regeneration of pancreatic beta cells in patients with Type 1 and Type 2 diabetes. Read more
Advances in cancer immunotherapy, a promising new area in cancer treatment that harnesses the body’s immune system or natural defenses to destroy cancer cells, are being led by Nina Bhardwaj, MD, PhD, Director of Immunotherapy, and Professor of Medicine (Hematology and Medical Oncology), at The Tisch Cancer Institute. Read more
A protein that promotes abnormal growth in melanoma cells has been identified for the first time by a team of researchers led by Emily Bernstein, PhD, Associate Professor of Oncological Sciences, and Dermatology, at the Icahn School of Medicine at Mount Sinai.
The novel discovery that the H2A.Z.2 protein is highly expressed in melanoma, appears to turn on the cell cycle, and makes melanoma cells grow faster, could also lead to therapeutic strategies that serve to inhibit cell proliferation. The results of Dr. Bernstein’s study were published in the July 2, 2015, issue of Molecular Cell. Read more
Surviving spouses of patients who received hospice care for three or more days more frequently reported reduced depressive symptoms after the patient’s death compared to spouses of patients who did not receive hospice, according to a study by Icahn School of Medicine at Mount Sinai researchers. The findings were published recently in JAMA Internal Medicine. Read more
The Office of Graduate Medical Education at Mount Sinai St. Luke’s and Mount Sinai Roosevelt recently held its ninth Annual Resident Research Fair. Five judges reviewed 61 abstracts and three residents received a certificate and prize. The winning abstracts were: “Radial vs. Femoral Access in Acute Coronary Syndrome: Decrease in Mortality, Major Adverse Cardiac Events and Bleeding–An Update Meta-analysis of Randomized Controlled Trials,” presented by Abel Casso-Dominguez, MD; “Review of Ascites and Spontaneous Bacterial Peritonitis (SBP) Diagnosis and Treatment for Cirrhotic Patients at MSSLR–A Follow Up,” by Vijay Dalapathi, MD; and “Randomized Controlled Trial of Insulin Detemir vs. Insulin NPH for the Treatment of Pregnant Women with Gestational Diabetes and Type 2 Diabetes,” by Kimberly Herrera, MD.