By Barnaby Nicolas, MSIS
In our monthly “Article Spotlight” series, we’re taking a closer look at highly cited articles by Mount Sinai faculty and researchers using PlumX to determine their altmetric impact. This month, we’re looking at an article by Dr. Scott H Sicherer, MD, Professor Pediatrics, Allergy and Immunology at the Icahn School of Medicine at Mount Sinai and Dr. Hugh Sampson, MD, Clinical Professor, Pediatrics, Allergy and Immunology at the Icahn School of Medicine at Mount Sinai. As you can see the by the Plum profile below, this particular article has had 221 abstract views and 26 imprints on social media!
Citation: Sicherer SH, Sampson HA. Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment. The Journal of allergy and clinical immunology. 2014;133(2):291-307
Article Summary: This is a review article that examines the advances in understanding and managing food allergies. The authors find that we are poised to witness a revolution in our approach to food allergy over the next several years as a result of deeper insights into genetics and the microbiome, incorporation of bioinformatics, and numerous approaches to treatment in preclinical and clinical studies.
BACKGROUND: This review focuses on advances and updates in the epidemiology, pathogenesis, diagnosis, and treatment of food allergy over the past 3 years since our last comprehensive review. On the basis of numerous studies, food allergy likely affects nearly 5% of adults and 8% of children, with growing evidence of an increase in prevalence. Potentially rectifiable risk factors include vitamin D insufficiency, unhealthful dietary fat, obesity, increased hygiene, and the timing of exposure to foods, but genetics and other lifestyle issues play a role as well. Interesting clinical insights into pathogenesis include discoveries regarding gene-environment interactions and an increasing understanding of the role of nonoral sensitizing exposures causing food allergy, such as delayed allergic reactions to carbohydrate moieties in mammalian meats caused by sensitization from homologous substances transferred during tick bites. Component-resolved diagnosis is being rapidly incorporated into clinical use, and sophisticated diagnostic tests that indicate severity and prognosis are on the horizon. Current management relies heavily on avoidance and emergency preparedness, and recent studies, guidelines, and resources provide insight into improving the safety and well-being of patients and their families. Incorporation of extensively heated (heat-denatured) forms of milk and egg into the diets of children who tolerate these foods, rather than strict avoidance, represents a significant shift in clinical approach. Recommendations about the prevention of food allergy and atopic disease through diet have changed radically, with rescinding of many recommendations about extensive and prolonged allergen avoidance. Numerous therapies have reached clinical trials, with some showing promise to dramatically alter treatment. Ongoing studies will elucidate improved prevention, diagnosis, and treatment.